Assen is extremely narrow with little to no run-off, it's a proper oldschool circuit. Nailing the setup will define whether you can keep your bike on the track. Here's our setup guide for MotoGP 22!
Tyres are the least of your worries around Assen. The circuit doesn't have many high-speed corners, so you can afford to go with a soft on the front and a medium on the rear.
The front suspension needs to be a mix of settings that are geared towards stability or responsiveness. The front pre-load value is down at 2, with the oil quality and spring hardness at 4 each.
The swingarm compression and extension both should be around 5 each.
The rear suspension should be around middle of the road to strike a good compromise. The shock absorber compression and extension need to be up at 5, with the rear pre-load value also up at 5.
The swingarm connector (4) and the rear spring hardness (3) should be set slightly lower.
The Vehicle Geometry should be slightly on the low side to help responsiveness. On a narrow track like Assen, you need to ensure that the bike's steering is very accurate.
The steering head inclination is up at 4, with the trail down at 2. Steering plate position is down at 3, with the rear swingarm at 4.
The gears in the Netherlands are set low for the lower gears and high for the higher gears. This is to allow for good acceleration out of the slow corners, but to also avoid hitting the rev limiter going down the back straight.
The slipper clutch should be around 4 to allow for better stability.
You've got several big stops around the Dutch circuit, so you'll need strong brakes. These are fairly spread out though, so you can go with the 340 mm high mass brakes on the front, with 220 mm on the rear.
Surprsingly, you won't need to use the electronic aids quite as much at Assen. You'll still need to lean on them though, with the Traction Control set to 3.
Engine Braking also should be at 3 in order to help aid shaving speed through the middle and final sectors.
Anti-wheelie also has to be at around 3 to prevent the front wheel from flying off the ground. With this being the Netherlands though, you won't have to worry about that.
Power mapping is best at 3 for a flying lap, but you'll need to turn this around during some points in the race. This is to save fuel and the engine. All of these can be adjusted out on track using the HUD in the bottom-right of the screen.